Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents

ALTINTOP M. D., SEVER B., ÖZDEMİR A., ILGIN S., ATLI EKLİOĞLU Ö., Turan-Zitouni G., ...Daha Fazla

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.18, sa.11, ss.1606-1616, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1871520618666180509111351
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1606-1616
  • Anahtar Kelimeler: Benzothiazole, thiadiazole, anticancer activity, apoptosis, DNA synthesis, human hepatocellular carcinoma, IN-VITRO EVALUATION, BIOLOGICAL EVALUATION, DESIGN, INHIBITORS, 1,3,4-OXADIAZOLE, BENZOTHIAZOLES, CYTOTOXICITY, ANTIFUNGAL, MOLECULES, PROGRESS
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-1(5-(arylamino)-1,3,4-thiadiazol-2-yl)thiolacetamides (1-14) was described and their cytotoxic effects on A549 human lung adenocarcinoma, MCF-7 human breast adenocarcinoma, HepG2 human hepatocellular carcinoma and NIH/3T3 mouse embryonic fibroblast cell lines were investigated using Mil' assay.