Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents

ALTINTOP M. D., Abu Mohsen U., KARACA H., CANTÜRK Z., ÖZDEMİR A.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.11, no.10, pp.1199-1203, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 10
  • Publication Date: 2014
  • Doi Number: 10.2174/1570180811666140717185937
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1199-1203
  • Keywords: Antimicrobial activity, pyrazole, thiazole, BIOLOGICAL EVALUATION, RESISTANCE
  • Anadolu University Affiliated: Yes

Abstract

In the present study, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-arylthiazol-2-yl)] derivatives (3a-h) were obtained via the reaction of 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide] (2) with phenacyl bromides. The synthesized compounds were investigated for their antimicrobial activity against various bacteria and Candida species. Among these derivatives, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-(4-chlorophenyl)thiazol-2-yl)] (3b) and 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole- 1-(4-(4-methoxyphenyl) thiazol-2-yl)] (3d) showed notable antimicrobial activity.