Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents
LETTERS IN DRUG DESIGN & DISCOVERY, vol.11, no.10, pp.1199-1203, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 11 Issue: 10
- Publication Date: 2014
- Doi Number: 10.2174/1570180811666140717185937
- Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1199-1203
- Keywords: Antimicrobial activity, pyrazole, thiazole, BIOLOGICAL EVALUATION, RESISTANCE
- Anadolu University Affiliated: Yes
Abstract
In the present study, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-arylthiazol-2-yl)] derivatives (3a-h) were obtained via the reaction of 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide] (2) with phenacyl bromides. The synthesized compounds were investigated for their antimicrobial activity against various bacteria and Candida species. Among these derivatives, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-(4-chlorophenyl)thiazol-2-yl)] (3b) and 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole- 1-(4-(4-methoxyphenyl) thiazol-2-yl)] (3d) showed notable antimicrobial activity.