Synthesis and antimicrobial activity evaluation of new hydrazide derivatives Yeni Hidrazid Türevlerinin Sentezi ve Bunların Antimikrobiyal Aktivitelerinin Deǧerlendirilmesi

Turan Zitouni G., Özdem A., KAPLANCIKLI Z. A., Revial G., DEMİRCİ F.

Turkish Journal of Pharmaceutical Sciences, vol.8, no.3, pp.199-206, 2011 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 3
  • Publication Date: 2011
  • Journal Name: Turkish Journal of Pharmaceutical Sciences
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.199-206
  • Keywords: 5,6,7,8-tetrahydro-2-naphthol, Aldehydes, Antimicrobial activity, Hydrazide
  • Anadolu University Affiliated: Yes


The enhancement of bacterial resistance of pathogens to currently available antibiotics constitutes a serious public health threat. Therefore, intensive efforts are underway worldwide to develop new antimicrobial agents. To identify compounds with a potent antimicrobial profile, we designed and synthesized some hydrazide derivatives 1a-e. The chemical structures of the compounds were elucidated by elemental analyses, IR, 1H-NMR, 13C-NMR and FAB+-MS spectral data. Their antimicrobial activities against to E. coli (NRRL B-3008), Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 27853), Proteus vulgaris (NRRL B-123), Salmonella typhimurium (ATCC 13311), Methicillin-resistant Staphylococcus aureus (MRSA) (clinic isolate), Candida albicans (NRRL Y-12983) and Candida parapsilosis (NRRL Y-12696) were investigated. The results showed that all of the tested compounds were inactive against the test organism.