Design, synthesis and apoptotic effects of novel benzoxazole compounds

Kaya B., YURTTAŞ L., AKALIN ÇİFTÇİ G., Aksoy M. O.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, cilt.78, sa.11-12, ss.433-440, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 11-12
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1515/znc-2023-0099
  • Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.433-440
  • Anahtar Kelimeler: 1,3,4-oxadiazole, benzoxazole, hydrazone, lung cancer, MTT
  • Anadolu Üniversitesi Adresli: Evet

Özet

A series of new benzoxazole-hydrazone and benzoxazole-1,3,4-oxadiazole derivatives have been designed, synthesized and evaluated as cytotoxic agents toward human A549 lung cancer cells. Compounds 3d, 3e, 5b, 5c, 5d and 5e were the most potent compounds with IC50 values of <3.9, 10.33, 11.6, 5.00, <3.9 and 4.5 mu g/mL, respectively, which are higher than reference drug cisplatin (IC50 = 19.00 mu g/mL). The flow cytometry-based apoptosis detection assay was performed to determine their effects on apoptosis in A549 cells. All tested compounds induced apoptosis in A549 cell line.