Antimicrobial and anticholinesterase activities of the essential oils isolated from Salvia dicroantha Stapf., Salvia verticillata L. subsp amasiaca (Freyn and Bornm.) Bornm. and Salvia wiedemannii Boiss.

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Atıf İçin Kopyala

KUNDUHOĞLU B., KÜRKÇÜOĞLU M., DURU M. E., BAŞER K. H. C.

JOURNAL OF MEDICINAL PLANTS RESEARCH, cilt.5, sa.29, ss.6484-6490, 2011 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 5 Sayı: 29
• Basım Tarihi: 2011
• Doi Numarası: 10.5897/jmpr11.220
• Dergi Adı: JOURNAL OF MEDICINAL PLANTS RESEARCH
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.6484-6490
• Anahtar Kelimeler: Salvia dicroantha, Salvia verticillata subsp amasiaca, Salvia wiedemannii, essential oil, antimicrobial activity, anticholinesterase activity, minimum inhibitory concentrations (MICs), DEMENTIA
• Anadolu Üniversitesi Adresli: Evet

Özet

In this study, the essential oil compositions and antimicrobial and anticholinesterase activities of three Turkish endemic Salvia species were investigated. The gas chromatography (GC) and gas chromatography - mass spectrometry (GC-MS) analysis of the essential oils obtained from Salvia dicroantha, Salvia verticillata subsp. amasiaca, and Salvia wiedemannii showed that the major constituents were caryophyllene oxide (22.4%), Germacrene D (36.6%), and a-pinene (36.2%), respectively. All essential oils exhibited antimicrobial activity against tested Gram-positive and Gram-negative bacteria, and test yeast strains. The minimum inhibitory concentrations (MICs) of oils ranged from 12.5 to 50.0 mu l/ml. Additionally, essential oils were more active than standard antifungals, inhibiting test strains of yeasts such as Candida albicans, Candida glabrata, and Saccharomyces cerevisiae. At 400 mu M concentration, the essential oil of S. wiedemannii had moderate acetylcholinesterase (55.95+/-2.01%), and butyrylcholinesterase (50.97+/-3.12%) inhibitory activity, while other two species no activity against both enzymes.