New Adamantyl Chalcones: Synthesis, Antimicrobial and Anticancer Activities

Tabbi A., Tebbani D., Caporale A., Saturnino C., Nabavi S. F., Giuseppe P., ...More

CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol.17, no.4, pp.498-506, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 17 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.2174/1568026616666160824121935
  • Journal Name: CURRENT TOPICS IN MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.498-506
  • Keywords: Adamantyl chalcones, Antimicrobial activity, Antifungal activity, Anticancer activity, MiaPaca2, NMR, ANTIINFLAMMATORY ACTIVITIES, AMANTADINE HYDROCHLORIDE, ANTIVIRAL ACTIVITY, ANTI-HIV, DERIVATIVES, AGENTS, ANTIMALARIAL, FLAVONOIDS, CELLS, CYTOTOXICITY
  • Anadolu University Affiliated: Yes

Abstract

Background: A new variety of adamantyl chalcones (2, 3a-o) were efficiently prepared by Claisen-Schmidt reaction of 4-adamantyl acetophenone 2 with a serie of aromatic aldehydes in good yields. Their structures were confirmed by spectroscopic data, and the relative configuration of 3d was confirmed by X-ray crystallography. All synthesized chalcones were tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus and displayed strong antibacterial activity against Enterococcus faecali 29212, Pseudomonas aeruginosa ATCC27853, Escherichia coli and interesting antifungal activity against Candida glabrata ATCC 90030.