New Adamantyl Chalcones: Synthesis, Antimicrobial and Anticancer Activities

Tabbi A., Tebbani D., Caporale A., Saturnino C., Nabavi S. F., Giuseppe P., ...Daha Fazla

CURRENT TOPICS IN MEDICINAL CHEMISTRY, cilt.17, sa.4, ss.498-506, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 17 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1568026616666160824121935
  • Dergi Adı: CURRENT TOPICS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.498-506
  • Anahtar Kelimeler: Adamantyl chalcones, Antimicrobial activity, Antifungal activity, Anticancer activity, MiaPaca2, NMR, ANTIINFLAMMATORY ACTIVITIES, AMANTADINE HYDROCHLORIDE, ANTIVIRAL ACTIVITY, ANTI-HIV, DERIVATIVES, AGENTS, ANTIMALARIAL, FLAVONOIDS, CELLS, CYTOTOXICITY
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: A new variety of adamantyl chalcones (2, 3a-o) were efficiently prepared by Claisen-Schmidt reaction of 4-adamantyl acetophenone 2 with a serie of aromatic aldehydes in good yields. Their structures were confirmed by spectroscopic data, and the relative configuration of 3d was confirmed by X-ray crystallography. All synthesized chalcones were tested against a panel of Gram-positive and Gram-negative bacteria and pathogenic fungus and displayed strong antibacterial activity against Enterococcus faecali 29212, Pseudomonas aeruginosa ATCC27853, Escherichia coli and interesting antifungal activity against Candida glabrata ATCC 90030.