The effects of atorvastatin on antioxidant/antiinflammatory properties of HDLs in hypercholesterolemics

AKALIN ÇİFTÇİ G., Ertorun I., AKALIN A., ALATAŞ İ. Ö., MUSMUL A.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.2, pp.345-351, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1311-91
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.345-351
  • Keywords: Antioxidant/antiinflammatory high-density lipoprotein, atorvastatin, hypercholesterolemia, oxidative stress, ASYMMETRIC DIMETHYLARGININE, REDUCTASE INHIBITORS, OXIDATIVE STRESS, APOLIPOPROTEIN-B, SERUM, PARAOXONASE-1, LIPOPROTEIN(A), CHOLESTEROL, EXPRESSION, THERAPY
  • Anadolu University Affiliated: Yes

Abstract

Background/aim: Hypercholesterolemia is characterized by changes in lipid profile, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in hypercholesterolemic subjects treated with atorvastatin. In this study, we aimed to evaluate effects of atorvastatin treatment on functionality of HDL, oxidative stress, and endothelial functions in hypercholesterolemic subjects.