Opioid system mediated anti-nociceptive effect of agomelatine in mice

Kasap M., CAN Ö. D.

LIFE SCIENCES, vol.163, pp.55-63, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 163
  • Publication Date: 2016
  • Doi Number: 10.1016/j.lfs.2016.08.031
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.55-63
  • Keywords: Agomelatine, Opioid receptor, Hot-plate test, Tail-clip test, Acetic acid-induced writhing test, DOUBLE-BLIND, ANTIDEPRESSANT EFFICACY, ANALGESIC ACTION, POOLED ANALYSIS, MELATONIN, RECEPTOR, MT2, HYPERALGESIA, INVOLVEMENT, NOCICEPTION
  • Anadolu University Affiliated: Yes


Aims: This study was planned to examine the antinociceptive efficacy of agomelatine against acute mechanical, thermal, and chemical nociceptive stimuli, as well as to determine the opioid receptor subtypes mediating these effects.