SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW HYDRAZONE DERIVATIVES BEARING PYRIMIDINE RING AS ANALGESIC AND ANTI-INFLAMMATORY AGENTS

Akdag K., ÜNAL G., TOK F., ARICIOĞLU F., TEMEL H. E., KAYMAKÇIOĞLU B.

ACTA POLONIAE PHARMACEUTICA, cilt.75, sa.5, ss.1147-1159, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75 Sayı: 5
  • Basım Tarihi: 2018
  • Doi Numarası: 10.32383/appdr/86743
  • Dergi Adı: ACTA POLONIAE PHARMACEUTICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1147-1159
  • Anahtar Kelimeler: Hydrazones, analgesic activity, anti-inflammatory activity, ANTIFUNGAL ACTIVITY, DESIGN, ANTIOXIDANT, INHIBITION
  • Anadolu Üniversitesi Adresli: Evet

Özet

New hydrazone derivatives were synthesized from 4-chloro-2-(methylthio) pyrimidine-5-carbohydrazide. IR, 1H-NMR, 13C-NMR, mass spectral data and elemental analysis characterized synthesized compounds. All compounds were investigated for analgesic and anti-inflammatory activity with hot plate test and biochemical assay, respectively. The results of anti-inflammatory activity showed that compound 2t had maximal lipoxygenase (LOX) inhibition (66.30%) whereas inhibitions of 2a, 2c, 2i, 2k, 2l, 2m, 2p, 2s, and 2u were observed between approximately 45-15%. Our results also indicated that 15 compounds of 21 had an analgesic effect in hot plate test. Analgesic effect of 2l, 2s, 2t began earlier than others while the effect of 2i began at the latest time. According to the activity results, compound 2t have both significant analgesic and anti-inflammatory effects.