Trimetazidine-induced enhancement of myocardial recovery during reperfusion: A comparative study in diabetic and non-diabetic rat hearts

Ikizler M., Erkasap N., Dernek S., BATMAZ B., Kural T., Kaygisiz Z.

ARCHIVES OF MEDICAL RESEARCH, vol.37, no.6, pp.700-708, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.1016/j.arcmed.2006.01.008
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.700-708
  • Keywords: trimetazidine, diabetes mellitus, ischemia/reperfusion, protection, heart, SUBSTRATE METABOLISM, GLUCOSE-OXIDATION, FATTY-ACIDS, INSULIN, MELLITUS, DISEASE, CARDIOMYOPATHY, INJURY
  • Anadolu University Affiliated: Yes


Background. Diabetes mellitus (DM) is a major predisposing factor for ischemic heart disease. Metabolic disturbances in diabetic heart including impaired myocardial glucose uptake and elevated plasma free fatty acids and increased rate of fatty acid beta-oxidation are probably important contributing factors to greater mortality. Trimetazidine (TMZ), a well-studied anti-ischemic agent, has been demonstrated to be beneficial in treatment of coronary artery disease as well as in treatment of diabetic patients. However, studies reporting the effects of the drug against global myocardial ischemia/reperfusion injury, particularly in diabetic hearts, are rare. This study was mainly aimed to investigate the cardioprotective action of TMZ against global ischemia in diabetic hearts and to compare its protective efficiency level with non-diabetics.