In vitro cytotoxicity of monticellite based bioactive ceramic powder synthesized from boron derivative waste

Barutca B., KÖROĞLU L., AYAS E., Koparal A. T.

CERAMICS INTERNATIONAL, cilt.44, sa.7, ss.8094-8099, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 7
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.ceramint.2018.01.252
  • Dergi Adı: CERAMICS INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.8094-8099
  • Anahtar Kelimeler: Monticellite (CaMgSiO4), Bioactive ceramics, Cytotoxicity, Powder synthesis, Boron derivative waste, BONE REGENERATION, GLASS, SCAFFOLD
  • Anadolu Üniversitesi Adresli: Evet

Özet

The cytotoxicity of monticellite based bioactive ceramic powder, which was synthesized from boron derivative waste has been determined by in vitro assays of MTT, NRU, and JC-1 staining. The toxicity of powder on different mammalian cell lines (3T3-L1, HUVEC, CRL-2120) was evaluated at the concentrations of 10, 100, 200, 400 and 800 mu g/mL to justify its potential for biomedical applications. The obtained results showed that monticellite based bioactive ceramic powder possesses not only bioactive feature but also biocompatible characteristic at the concentration range of 10-200 mu g/mL. Hence, monticellite based bioactive ceramics have high potential as a bone graft substitute for bone void filling and coating applications.