Stereoselective and regioselective synthesis of N-substituted methyl 2-((azolyl)methyl)-3-arylacrylates from Baylis-Hillman acetates

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Ozenc A. K., ÇELİK İ., Kokten S.

TURKISH JOURNAL OF CHEMISTRY, cilt.41, sa.3, ss.323-334, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3906/kim-1607-35
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.323-334
  • Anahtar Kelimeler: Imidazole, benzimidazole, benzotriazole, Baylis Hillman acetates, N-substituted azole acrylates, ADDUCTS, FACILE, ACID, N-(2-AMINOBENZOYL)BENZOTRIAZOLE, ESTERIFICATION, BENZOTRIAZOLE, DERIVATIVES, IMIDAZOLES
  • Anadolu Üniversitesi Adresli: Evet

Özet

N-Substituted methyl 2-((azolyl)methyl)-3-arylacrylates were synthesized stereo- and regioselectively with one-pot reaction between Baylis-Hillman acetates and a suitable acylazole in the presence of K2CO3 as a base catalyst. The targeted N-substituted azole acrylates were efficiently obtained in good yields (39%-89%).