A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death

Mbaveng A. T., Ndontsa B. L., Kuete V., Nguekeu Y. M. M., ÇELİK İ., Mbouangouere R., ...Daha Fazla

PHYTOMEDICINE, cilt.43, ss.78-85, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.phymed.2018.03.035
  • Dergi Adı: PHYTOMEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.78-85
  • Anahtar Kelimeler: Ardisiacrispin B, Cell cycle distribution, Cytotoxicity, Ferroptosis, Mitochondrial membrane potential, Saponin, LEUKEMIA-CELLS, BREAST-CANCER, TUMOR-CELLS, MODES, TRANSPORTER, FLAVONOIDS, AUTOPHAGY, PUSILLA, LINES
  • Anadolu Üniversitesi Adresli: Evet

Özet

Introduction: Multidrug resistance of cancer cells constitutes a serious problem in chemotherapy and a challenging issue in the discovery of new cytotoxic drugs. Many saponins are known to display anti-cancer effects. In this study, the cytotoxicity and the modes of action of a naturally occuring oleanane-type tritepene saponin, ardisiacrispin B isolated from the fruit of Ardisia kivuensis Talon (Myrsinaceae) was evaluated on a panel of 9 cancer cell lines including various sensitive and drug-resistant phenotypes.