A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death

Mbaveng A. T., Ndontsa B. L., Kuete V., Nguekeu Y. M. M., ÇELİK İ., Mbouangouere R., ...More

PHYTOMEDICINE, vol.43, pp.78-85, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43
  • Publication Date: 2018
  • Doi Number: 10.1016/j.phymed.2018.03.035
  • Journal Name: PHYTOMEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.78-85
  • Keywords: Ardisiacrispin B, Cell cycle distribution, Cytotoxicity, Ferroptosis, Mitochondrial membrane potential, Saponin, LEUKEMIA-CELLS, BREAST-CANCER, TUMOR-CELLS, MODES, TRANSPORTER, FLAVONOIDS, AUTOPHAGY, PUSILLA, LINES
  • Anadolu University Affiliated: Yes

Abstract

Introduction: Multidrug resistance of cancer cells constitutes a serious problem in chemotherapy and a challenging issue in the discovery of new cytotoxic drugs. Many saponins are known to display anti-cancer effects. In this study, the cytotoxicity and the modes of action of a naturally occuring oleanane-type tritepene saponin, ardisiacrispin B isolated from the fruit of Ardisia kivuensis Talon (Myrsinaceae) was evaluated on a panel of 9 cancer cell lines including various sensitive and drug-resistant phenotypes.