PHYTOMEDICINE, vol.43, pp.78-85, 2018 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Ardisiacrispin B, Cell cycle distribution, Cytotoxicity, Ferroptosis, Mitochondrial membrane potential, Saponin, LEUKEMIA-CELLS, BREAST-CANCER, TUMOR-CELLS, MODES, TRANSPORTER, FLAVONOIDS, AUTOPHAGY, PUSILLA, LINES
Anadolu University Affiliated:
Introduction: Multidrug resistance of cancer cells constitutes a serious problem in chemotherapy and a challenging issue in the discovery of new cytotoxic drugs. Many saponins are known to display anti-cancer effects. In this study, the cytotoxicity and the modes of action of a naturally occuring oleanane-type tritepene saponin, ardisiacrispin B isolated from the fruit of Ardisia kivuensis Talon (Myrsinaceae) was evaluated on a panel of 9 cancer cell lines including various sensitive and drug-resistant phenotypes.