A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death

Mbaveng, Armelle; Ndontsa, Blanche; Kuete, Victor; Nguekeu, Yves; ÇELİK, İLHAMİ; Mbouangouere, Roukayatou; Tane, Pierre; Efferth, Thomas

doi:10.1016/j.phymed.2018.03.035

A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death

Mbaveng A. T., Ndontsa B. L., Kuete V., Nguekeu Y. M. M., ÇELİK İ., Mbouangouere R., ...Daha Fazla

PHYTOMEDICINE, cilt.43, ss.78-85, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 43
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.phymed.2018.03.035
Dergi Adı: PHYTOMEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.78-85
Anahtar Kelimeler: Ardisiacrispin B, Cell cycle distribution, Cytotoxicity, Ferroptosis, Mitochondrial membrane potential, Saponin, LEUKEMIA-CELLS, BREAST-CANCER, TUMOR-CELLS, MODES, TRANSPORTER, FLAVONOIDS, AUTOPHAGY, PUSILLA, LINES
Anadolu Üniversitesi Adresli: Evet

Özet

Introduction: Multidrug resistance of cancer cells constitutes a serious problem in chemotherapy and a challenging issue in the discovery of new cytotoxic drugs. Many saponins are known to display anti-cancer effects. In this study, the cytotoxicity and the modes of action of a naturally occuring oleanane-type tritepene saponin, ardisiacrispin B isolated from the fruit of Ardisia kivuensis Talon (Myrsinaceae) was evaluated on a panel of 9 cancer cell lines including various sensitive and drug-resistant phenotypes.