Synthesis and Antifungal Activities of Some Aryl Naphthofuran Ketoximes
LETTERS IN DRUG DESIGN & DISCOVERY, cilt.8, sa.8, ss.758-762, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 8
- Basım Tarihi: 2011
- Doi Numarası: 10.2174/157018011796576097
- Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.758-762
- Anahtar Kelimeler: Aryl naphthofuran ketoximes, Aryl naphthofuran O-methylketoximes, Aryl naphthofuran ketoxime acetates, Antifungal activity, OXIME ETHER DERIVATIVES, ANTIMICROBIAL ACTIVITY, FUNGICIDAL ACTIVITY, CANDIDA-ALBICANS, ANTIBACTERIAL, BENZOFURAN, SORDARICIN, AGENTS
- Anadolu Üniversitesi Adresli: Evet
Özet
In this study, some aryl naphtho[2,1-b] furan-2-yl ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, H-1-NMR and MASS spectroscopic data and elemental analyses results. Antifungal activities of the compounds were tested against Candida albicans (two strains), Candida glabrata, Candida tropicalis and Candida parapsilosis using a microbroth dilution technique. The results showed that the compounds displayed minimum inhibitory concentrations, 7.8-625 mu g/mL.