Phytochemical Investigation of Endemic Sideritis cypria Post

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Hanoglu D. Y., Hanoglu A., Yusufoglu H., DEMİRCİ B., Baser K. H. C., ÇALIŞ İ., ...Daha Fazla

RECORDS OF NATURAL PRODUCTS, cilt.14, sa.2, ss.105-115, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.25135/rnp.140.18.11.1079
  • Dergi Adı: RECORDS OF NATURAL PRODUCTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, ABI/INFORM, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.105-115
  • Anahtar Kelimeler: Sideritis, phytochemistry, ent-kaurane diterpenes, iridoids, flavonoids, essential oil, IN-VITRO-PROPAGATION, CHEMICAL-COMPOSITION, ESSENTIAL OILS, ANTIMICROBIAL ACTIVITY, FLAVONOID AGLYCONES, 8-HYDROXYFLAVONE GLYCOSIDES, ANTIOXIDANT ACTIVITIES, PHENOLIC-COMPOUNDS, ACETYLATED ALLOSE, CANARY-ISLANDS
  • Anadolu Üniversitesi Adresli: Evet

Özet

Non-polar and polar compounds were isolated from the leaves and chemical composition of the essential oil from aerial parts of Sideritis cypria endemic in Northern Cyprus was also determined. The structures of all the isolated compounds were elucidated by means of spectroscopic (UV, NMR: 1D and 2D-NMR: H-1, C-13, COSY, HSQC, HMBC) methods and comparison with literature data. The essential oil composition of the plant material was analysed by GC-FID and GC-MS, simultaneously. To the best of our knowledge, secondary metabolites of this endemic species were determined for the first time. As a result, two mixtures of four entkaurane diterpenes; sidol (1) and isosidol (2), linearol (3) and isolinearol (4); four phenylethanoid glycosides; verbascoside (5), lavandulifolioside (6), leonoside A (7), leucoseptoside A (8); four flavone glycosides, apigenin-7 -O-glucopyrano side (9), isoscutellarein-7 -O[6'''-O-acetyl-allopyrano syl -(1 -> 2)-glucopyrano side] (10) and a mixture of apigenin-7-O-(4 ''-O-p-coumaroyl)-glucopyranoside (11) and apigenin-7-O-(3 ''-O-p-coumaroyl)-glucopyranoside (12) were elucidated. 7-O-acetyl-8-epi-loganic acid (13), an iridoid glycoside, was reported herein for the first time for genus Sideritis. In addition, major compounds of the essential oil were determined as alpha-pinene (14.73 +/- 0.15%), beta-pinene (16.60 +/- 0.20%), beta-phellandrene (17.83 +/- 0.23%) and epi-cubebol (7.70 +/- 0.20%), respectively.