Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy
LIFE SCIENCES, vol.95, no.1, pp.9-13, 2014 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 95 Issue: 1
- Publication Date: 2014
- Doi Number: 10.1016/j.lfs.2013.12.012
- Journal Name: LIFE SCIENCES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.9-13
- Keywords: Zonisamide, Neuropathic pain, Serotonergic descending pain pathways, THERMAL HYPERALGESIA, NERVE INJURY, MECHANISMS, DRUGS, MICE
- Anadolu University Affiliated: Yes
Abstract
Aims: The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role of serotonergic descending inhibitory pain pathways in antihyperalgesic effectiveness of zonisamide in the streptozotocin-induced rat model for painful diabetic neuropathy.