Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy

BEKTAŞ TÜRKMEN N., ARSLAN R., ÖZTÜRK Y.

LIFE SCIENCES, cilt.95, sa.1, ss.9-13, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 95 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.lfs.2013.12.012
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.9-13
  • Anahtar Kelimeler: Zonisamide, Neuropathic pain, Serotonergic descending pain pathways, THERMAL HYPERALGESIA, NERVE INJURY, MECHANISMS, DRUGS, MICE
  • Anadolu Üniversitesi Adresli: Evet

Özet

Aims: The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role of serotonergic descending inhibitory pain pathways in antihyperalgesic effectiveness of zonisamide in the streptozotocin-induced rat model for painful diabetic neuropathy.