Ferritin based bionanocages as novel biomemory device concept

Elmas S. N. K., GÜZEL R., Say M. G., Ersoz A., Say R.

BIOSENSORS & BIOELECTRONICS, vol.103, pp.19-25, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 103
  • Publication Date: 2018
  • Doi Number: 10.1016/j.bios.2017.12.011
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.19-25
  • Keywords: Ferritin, Cage protein, Bionanocage, ANADOLUCA, Apoferritin, Biomemory, IRON STORAGE, GRAPHENE, METALLOPROTEINS, APOFERRITIN, PROTEINS, CELLS, LAYER
  • Anadolu University Affiliated: Yes


Ferritin is an iron cage having protein, capable of extracting metal ions in their cages and a consequence of the electron transfer of metal ions in their cage by reduction and oxidation processes, electrochemical information storage devices can be designed. In this work, ferritin based protein biomemory substrate has been synthesized by using Amino Acid (monomer) Decorated and Light Underpinning Conjugation Approach (ANADOLUCA) method, which utilizes photosensitive electron transfer based microemulsion co-polymerization as nanobead form of ferritin. Protein substrate contains metal ions such as silver and copper or metal ion pairs namely, silver copper (Janus bionanocage) and co-polymeric shell of the photosensitive crosslinker protein. The redox behavior of bionanocages differentiates electrochemical "writing" and "erase states depending on these metal ions (silver or copper) or metal ion pairs. The bionanocages based biomemory substrates have been immobilized using graphene modified glassy carbon electrodes and the memory functions of ferritin based bionanocages have been confirmed by chronoamperometry (CA) and open circuit potential amperometry (OCPA). The stability and durability of multi-state memory devices represent promising properties for future bioelectronic information technologies.