The synthesis of some triazolylphenothiazine derivatives and their antidepressant and anxiolytic activities

Turan-Zitouni G., KAPLANCIKLI Z. A., Kiliç F., Erol K.

Bollettino Chimico Farmaceutico, vol.141, no.3, pp.192-196, 2002 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 141 Issue: 3
  • Publication Date: 2002
  • Journal Name: Bollettino Chimico Farmaceutico
  • Journal Indexes: Scopus
  • Page Numbers: pp.192-196
  • Keywords: 1,2,4-triazole derivatives, 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives, Antidepressant and anxiolytic activity, Phenothiazine derivatives
  • Anadolu University Affiliated: Yes


10-[2-(4-Amino-5-mercapto-1,2,4-triazol-3-yl)ethyl]phenothiazine was prepared starting from 3-(10-phenothiaziniyl)propionic acid. This new triazole was employed in the synthesis of some Schiff bases and N-bridged heterocycles. All the newly synthesized compounds were characterized by analytical, IR, 1H-NMR and MASS Spectral studies. Some of the newly synthesized compounds were screened for their antidepressant and anxiolytic activities.