New Cyclohexylamine-dithiocarbamate Derivatives as Potential Anti-microbial Agents

YURTTAŞ L., KAYA ÇAVUŞOĞLU B., YILMAZ CANKILIÇ M., LEVENT S.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.14, no.11, pp.1308-1315, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 11
  • Publication Date: 2017
  • Doi Number: 10.2174/1570180814666170412121402
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1308-1315
  • Keywords: Dithiocarbamate, lipophilicity, antifungal activity, antibacterial activity, ADME, agents, ANTIBACTERIAL ACTIVITY, LIPOPHILICITY, DISCOVERY
  • Anadolu University Affiliated: Yes

Abstract

Background: In this study, 2-(substituted-sulfanyl)-N, N-dicyclohexylacetamide derivatives (2a-2g) and 2-(dicyclohexylamino)-2-oxoethyl-1-substituted carbodithioate derivatives (2h-2m) were synthesized and screened for their antimicrobial activity.