Preparation of new molecularly imprinted quartz crystal microbalance hybride sensor system for 8-hydroxy-2 '-deoxyguanosine determination

Say R., Gultekin A., Ozcan A. A., DENİZLİ A., ERSÖZ A.

ANALYTICA CHIMICA ACTA, vol.640, no.1-2, pp.82-86, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 640 Issue: 1-2
  • Publication Date: 2009
  • Doi Number: 10.1016/j.aca.2009.03.022
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.82-86
  • Keywords: Molecular imprinted polymers, Quartz crystal microbalance, 8-Hydroxy-2 '-deoxyguanosine, Metal-chelate interaction, OXIDATIVE DNA-DAMAGE, SUBSTRATE-SELECTIVE POLYMERS, LIQUID-CHROMATOGRAPHY, 8-HYDROXYDEOXYGUANOSINE, RECOGNITION, IMMUNOSENSOR, REMOVAL, MARKER, URINE
  • Anadolu University Affiliated: Yes


The routine measurement of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in biological samples is a difficult analytical problem due to the low levels of the analyte and complex matrix. A new 8-OHdG imprinted quartz crystal microbalance (QCM) sensor has been developed for selective determination of 8-OHdG in serum samples. To fulfil the desired results, we have used methacryloyl aminoantipyrine-Fe(III) [MAAP-Fe(III)] and methacryloyl histidine-Pt(II) [MAH-Pt(II)] as metal-chelating monomers via double metal coordination-chelation interactions for the preparation of additional selective molecular imprinted polymers (MIP).