Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4-aryl-2-thiazolyl])hydrazone]-1H-indol-2,3-diones


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YURTTAŞ L., Ertaş M., Cankılıç M. Y., Demirayak Ş.

Acta Pharmaceutica Sciencia, vol.55, no.1, pp.51-58, 2017 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.23893/1307-2080.aps.0554
  • Journal Name: Acta Pharmaceutica Sciencia
  • Journal Indexes: Scopus
  • Page Numbers: pp.51-58
  • Keywords: Antimycobacterial activity, Indole, Isatin, Thiazole
  • Anadolu University Affiliated: Yes

Abstract

© 2017, University of Istanbul. All rights reserved.A series of 3-[(4-aryl-2-thiazolyl)hydrazone]-1H-indol-2,3-dione derivatives (2a-f) were designed and synthesized using isatin as starting material. The obtained thiazole compounds were screened to investigate their antituberculosis activity against Mycobacterum tuberculosis H37RV (ATCC 27294). Among them, two compounds 2c and 2d were displayed antitubercular potential two-fold greater than standard drugs.