Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4-aryl-2-thiazolyl])hydrazone]-1H-indol-2,3-diones

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YURTTAŞ L., Ertaş M., Cankılıç M. Y., Demirayak Ş.

Acta Pharmaceutica Sciencia, cilt.55, sa.1, ss.51-58, 2017 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.23893/1307-2080.aps.0554
  • Dergi Adı: Acta Pharmaceutica Sciencia
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.51-58
  • Anahtar Kelimeler: Antimycobacterial activity, Indole, Isatin, Thiazole
  • Anadolu Üniversitesi Adresli: Evet

Özet

© 2017, University of Istanbul. All rights reserved.A series of 3-[(4-aryl-2-thiazolyl)hydrazone]-1H-indol-2,3-dione derivatives (2a-f) were designed and synthesized using isatin as starting material. The obtained thiazole compounds were screened to investigate their antituberculosis activity against Mycobacterum tuberculosis H37RV (ATCC 27294). Among them, two compounds 2c and 2d were displayed antitubercular potential two-fold greater than standard drugs.