Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most widely prescribed medications in the World [1]. NSAIDs are used for the treatment of musculoskeletal disorders such as osteoarthritis and rheumatoid arthritis. Dexketoprofen trometamol is the dextrorotatory enantiomer of ketoprofen formulated as tromethamine salt. Dexketoprofen trometamol’s distribution and elimination half-lives are 0.35 and 1.65 hr, respectively. SLNs are colloidal carriers developed especially for the delivery of lipophilic compounds at the beginning of the 1990s as an alternative system to existing traditional carriers like emulsions, liposomes and polymeric nanoparticles. Preparing and characterizing SLNs for oral controlled analgesic delivery was aimed in this study. Dynasan® 114 (Trimyristin/Glyceryl Trimyristate) was selected as the solid lipid. Dexketoprofen tromethamol loaded SLNs were prepared by hot homogenization method followed by probe ultrasonication and characterization was achieved by particle size/PDI and zeta potential measurements, DCS thermograms, SEM imaging FT-IR and NMR spectroscopic analyses.