Effects of acetylsalicylate overdose on lipopolysaccharide-induced lung injury in rats: the role of the VEGF

Akyuz F., Aydin O., AYDIN T., TEKİN N., TEMEL H. E., BURUKOĞLU DÖNMEZ D., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.37, no.3, pp.231-238, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.5505/tjb.2012.02411
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.231-238
  • Keywords: Acetylsalicylate, lipopolysaccharide, lung injury, vascular endothelial growth factor, ENDOTHELIAL GROWTH-FACTOR, NITRIC-OXIDE, ASPIRIN, EXPRESSION
  • Anadolu University Affiliated: Yes

Abstract

Aim: Vascular endothelial growth factor production is decreased depending on the alveolar epithelial cell damage. Acute over expression of vascular endothelial growth factor in lung tissue contributes to the formation permeability. Excessive doses of acetylsalicylate (ASA) may induce pulmonary edema by increasing pulmonary vascular permeability. In this study, the effects of acetylsalicylate overdoses were evaluated on bronchoalveolar lavage fluid levels of vascular endothelial growth factor in the presence of lipopolysaccharide-induced lung injury in rats.