Some urea and thiourea derivatives bearing 1,2,4-triazole ring and their anti-acetylcholinesterase activities
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.4, no.2, pp.85-89, 2014 (ESCI)
- Publication Type: Article / Article
- Volume: 4 Issue: 2
- Publication Date: 2014
- Doi Number: 10.5455/musbed.20140326030221
- Journal Name: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
- Journal Indexes: Emerging Sources Citation Index (ESCI)
- Page Numbers: pp.85-89
- Keywords: Urea, thiourea, 1,2,4-triazole, anti-acetylcholinesterase activity, CHOLINERGIC HYPOTHESIS, ALZHEIMERS-DISEASE, ACETYLCHOLINESTERASE, INHIBITION, DESIGN, DRUG
- Anadolu University Affiliated: Yes
Abstract
Objective: Twenty different urea and thiourea derivatives were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) using a modification of Ellman's spectrophotometric method.