Synthesis and Biological Evaluation of Some Hydrazone Derivatives as Anti-inflammatory Agents

KAPLANCIKLI Z. A., ALTINTOP M. D., ÖZDEMİR A., Turan-Zitouni G., Khan S. I., Tabanca N.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.9, sa.3, ss.310-315, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.2174/157018012799129828
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.310-315
  • Anahtar Kelimeler: Hydrazone, Anti-inflammatory activity, Cytotoxicity, Antioxidant activity, ANTIMICROBIAL ACTIVITY, ACID HYDRAZIDE, INHIBITION
  • Anadolu Üniversitesi Adresli: Evet

Özet

In the present study, some hydrazone derivatives were synthesized via the reaction of 3-cyclohexylpropionic acid hydrazide with various benzaldehydes. The chemical structures of the compounds were elucidated by spectroscopic techniques such as IR, H-1-NMR and FAB-MS and elemental analyses. The compounds were evaluated for their antiinflammatory and cytotoxic activities. Anti-inflammatory activity was determined in terms of inhibition of NF-kappa B, ROS generation and iNOS activity. Several derivatives inhibited NF-kappa B and iNOS, but no effect was observed on intracellular ROS generation. Furthermore no cytoxicity was observed. Biological activity compared with the chemical structural information suggests that different functional groups on the phenyl ring influence the physicochemical properties and thus modulate biological activity.