Research Information System
in: Comprehensive Analytical Chemistry, Elsevier B.V., 2026
White Analytical Chemistry (WAC) is a development of analytical science taking the concepts of Green Analytical Chemistry (GAC) and developing a full model based on three main factors: analytical performance, environmental impact and practical feasibility. This strategy is also known as the Red-Green-Blue (RGB) model as it focuses on the balance between sensitivity, accuracy and precision and sustainability and economic viability. WAC has historical background in the green chemistry movement of the 1990s which aimed at reducing environmental and health hazards in chemical operations. WAC presents a more comprehensive assessment model, with a limitation of GAC because it also addresses other factors that impact the quality of methods used. The contemporary era of WAC has contributed to the advancement of novel analytical approaches and devices, such as the Green Analytical Procedure Index (GAPI) and Analytical GREEnness Metric (AGREE) so that the practices of analytics can be sustainable. It is this paradigm shift of analytical science that has resulted in more efficient, more environmentally friendly and more cost-effective means of analysis, which are rapidly being adopted in different industries especially in the pharmaceutical industry. Since WAC is still in its development, it is crucial in the development of sustainable scientific practices, as well as a more responsible and environmentally friendly future.