N-acylbenzotriazole mediated microwave assisted synthesis of protected and novel unprotected ferrocenoylamidoamino acids

HÜR D., Dal S. F. E., Varol G. A., HÜR E.

JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol.696, no.13, pp.2543-2548, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 696 Issue: 13
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jorganchem.2011.03.037
  • Journal Name: JOURNAL OF ORGANOMETALLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC), Current Chemical Reactions (CCR)
  • Page Numbers: pp.2543-2548
  • Keywords: Ferrocene, Amino acid, Acylbenzotriazole, Ferrocenoylamido amino acid, ALPHA-AMINO-ACIDS, EFFICIENT CONVERSION, C-ACYLATION, PEPTIDES, SECONDARY
  • Anadolu University Affiliated: Yes

Abstract

In this study, crystalline and chirally stable carboxyl-protected and novel unprotected N-ferrocenoyl amino acid derivatives of Ser, Cys, Ala, Phe, Trp, Asp and Asn have been prepared. These amino acids undergo substitution reaction with 1-(ferrocenylcarbonyl)-1H-benzotriazole, 1, in partially aqueous media under microwave irradiation. (C) 2011 Elsevier B.V. All rights reserved.