Novel Benzimidazole Derivatives: Cytotoxic and Apoptotic Properties on Lung Cancer Cell Line
LETTERS IN DRUG DESIGN & DISCOVERY, vol.17, no.10, pp.1227-1236, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 17 Issue: 10
- Publication Date: 2020
- Doi Number: 10.2174/157018017999200513091613
- Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE
- Page Numbers: pp.1227-1236
- Keywords: Benzimidazole, piperazine, anticancer activity, A549 lung cancer, cytotoxicity, apoptosis, ANTICANCER ACTIVITY, SAR
- Anadolu University Affiliated: Yes
Abstract
Background: Benzimidazole derivatives are privileged molecules known to have a wide variety of biological activities. In medicinal chemistry, due to the ring's structural similarity to nucleotides, its derivatives were investigated as new chemotherapeutic agents. Our research group have been studying 1,2-disubstituted benzimidazoles, including thiocarbamoyl group and their potential anticancer activity. Based on previous findings, we synthesized novel 1-[2-(4-substituted phenyl-2-oxoethyl)]-2-[(2/3/4-substituted phenylpiperidin-1-yl)thiocarbamoyl]benzimidazole derivatives (3a-o).