Cytotoxic effects of some perimidine derivatives on F2408 and 5Rp7 cell lines

IŞIKDAĞ İ., Incesu Z., Gülnaz D., ÖZKAY Y.

Fabad Journal of Pharmaceutical Sciences, vol.33, no.3, pp.135-143, 2008 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 3
  • Publication Date: 2008
  • Journal Name: Fabad Journal of Pharmaceutical Sciences
  • Journal Indexes: Scopus
  • Page Numbers: pp.135-143
  • Keywords: Antiproliferative effect, Cytotoxicity, Perimidine derivatives, Rat embryo fibroblast
  • Anadolu University Affiliated: Yes

Abstract

In this study twenty perimidine derivatives were prepared in order to seek their cytotoxic and antiproliferative effects on normal rat embryo fibroblast (F2408) and carcinogenic rat embryo fibroblast (5RP7) cell lines. Most of the compounds showed significant cytotoxicity on F2408 cell line. Least cytotoxic compounds were selected to examine their cytotoxic activity on 5RP7 cell line. However, selected compounds exhibited poor cytotoxicity on carcinogenic cells. Further investigation showed that antiproliferative effects of selected perimidine derivatives were similar on both cell lines.