Cytotoxic effects of some perimidine derivatives on F2408 and 5Rp7 cell lines

IŞIKDAĞ İ., Incesu Z., Gülnaz D., ÖZKAY Y.

Fabad Journal of Pharmaceutical Sciences, cilt.33, sa.3, ss.135-143, 2008 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 3
  • Basım Tarihi: 2008
  • Dergi Adı: Fabad Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.135-143
  • Anahtar Kelimeler: Antiproliferative effect, Cytotoxicity, Perimidine derivatives, Rat embryo fibroblast
  • Anadolu Üniversitesi Adresli: Evet

Özet

In this study twenty perimidine derivatives were prepared in order to seek their cytotoxic and antiproliferative effects on normal rat embryo fibroblast (F2408) and carcinogenic rat embryo fibroblast (5RP7) cell lines. Most of the compounds showed significant cytotoxicity on F2408 cell line. Least cytotoxic compounds were selected to examine their cytotoxic activity on 5RP7 cell line. However, selected compounds exhibited poor cytotoxicity on carcinogenic cells. Further investigation showed that antiproliferative effects of selected perimidine derivatives were similar on both cell lines.