Synthesis of Some New Thiazole Derivatives and Their Biological Activity Evaluation

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YURTTAŞ L., ÖZKAY Y., Gencer H., ACAR ÇEVİK U.

JOURNAL OF CHEMISTRY, vol.2015, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 2015
  • Publication Date: 2015
  • Doi Number: 10.1155/2015/464379
  • Journal Name: JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anadolu University Affiliated: Yes

Abstract

New 2-(4-arylpiperazine-1-yl)-N-[4-(2-(4-substituted phenyl)thiazol-4-yl)phenyl]acetamide derivatives were synthesized and evaluated for their antimicrobial and anticholinesterase activities. Acetylcholinesterase inhibitory activities of the compounds were found weak contrary to expectations. It is unlikely that antifungal activity of the compounds was found significant, especially against Candida parapsilosis.