Inhibitory effects of carvacrol on DMBA induced pulmonary tumorigenesis in rats
Acta Pharmaceutica Turcica, vol.40, no.2, pp.93-98, 1998 (Scopus)
- Publication Type: Article / Article
- Volume: 40 Issue: 2
- Publication Date: 1998
- Journal Name: Acta Pharmaceutica Turcica
- Journal Indexes: Scopus
- Page Numbers: pp.93-98
- Keywords: Antitumor activity, Carvacrol
- Anadolu University Affiliated: Yes
Abstract
Essential oils of various plant species rich in carvacrol have several ethnomedical uses for various diseases in Turkey. Carvacrol, which was obtained by fractional distillation of Origanun onites L essential oil was tested for lung tumors induced by DMBA in rats in vivo and it was found to have strong antitumor activity at 0.1 mg·kg-1 i.p. Although the mechanism of action of antitumor activity of carvacrol was not investigated in this study, evidences for an inhibitory effect on angiogenesis were observed.