Inhibitory effects of carvacrol on DMBA induced pulmonary tumorigenesis in rats

ZEYTİNOĞLU M., AYDIN S., ÖZTÜRK Y., Husnu K., Baser C.

Acta Pharmaceutica Turcica, cilt.40, sa.2, ss.93-98, 1998 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 2
  • Basım Tarihi: 1998
  • Dergi Adı: Acta Pharmaceutica Turcica
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.93-98
  • Anahtar Kelimeler: Antitumor activity, Carvacrol
  • Anadolu Üniversitesi Adresli: Evet

Özet

Essential oils of various plant species rich in carvacrol have several ethnomedical uses for various diseases in Turkey. Carvacrol, which was obtained by fractional distillation of Origanun onites L essential oil was tested for lung tumors induced by DMBA in rats in vivo and it was found to have strong antitumor activity at 0.1 mg·kg-1 i.p. Although the mechanism of action of antitumor activity of carvacrol was not investigated in this study, evidences for an inhibitory effect on angiogenesis were observed.