Inhibitory effects of carvacrol on DMBA induced pulmonary tumorigenesis in rats

ZEYTİNOĞLU M., AYDIN S., ÖZTÜRK Y., Husnu K., Baser C.

Acta Pharmaceutica Turcica, vol.40, no.2, pp.93-98, 1998 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 2
  • Publication Date: 1998
  • Journal Name: Acta Pharmaceutica Turcica
  • Journal Indexes: Scopus
  • Page Numbers: pp.93-98
  • Keywords: Antitumor activity, Carvacrol
  • Anadolu University Affiliated: Yes

Abstract

Essential oils of various plant species rich in carvacrol have several ethnomedical uses for various diseases in Turkey. Carvacrol, which was obtained by fractional distillation of Origanun onites L essential oil was tested for lung tumors induced by DMBA in rats in vivo and it was found to have strong antitumor activity at 0.1 mg·kg-1 i.p. Although the mechanism of action of antitumor activity of carvacrol was not investigated in this study, evidences for an inhibitory effect on angiogenesis were observed.