Greenness of lab-on-a-chip devices for analytical processes: Advances & future prospects

Agrawal A., YILDIZ Ü. Y., Hussain C. G., Kailasa S. K., KEÇİLİ R., Hussain C. M.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, cilt.219, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 219
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.jpba.2022.114914
  • Dergi Adı: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Analytical Abstracts, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Lab -on -a -chip devices, Analytical chemistry, Microextraction techniques, Green solvents, LIQUID-PHASE MICROEXTRACTION, BAR SORPTIVE EXTRACTION, SUPERCRITICAL-FLUID EXTRACTION, DEEP EUTECTIC SOLVENT, SINGLE-DROP MICROEXTRACTION, GAS-CHROMATOGRAPHY, MASS-SPECTROMETRY, PACKED SORBENT, IONIC-LIQUID, WATER SAMPLES
  • Anadolu Üniversitesi Adresli: Evet

Özet

Lab-on-a-chip devices have now-a-days become an important aspect of analytical/bioanalytical chemistry having wide range of applications including clinical diagnosis, drug screening, cell biology, environmental monitoring, food safety analysis etc. Conventional lab-on-a-chip devices generally employ chemicals that are not environmentally friendly and were commonly fabricated on hard plastic platform which are non-degradable and hence ignore the importance of green analytical chemistry. In today's scenario, it is highly imperative to protect our environment by using less toxic and environmentally friendly chemicals/solvents and biocompatible platforms. Accordingly, the present article comprehensively reviews on the various green aspects of lab-on-a-chip devices for analytical processes which aim at fabricating environmentally friendly and cost-effective downsized devices so that the risk factor at the user's end upon longer exposure as well as to the environment can be reduced. The decisive factors for the accomplishment of green aspects of lab-on-a-chip devices including sample preparation using lab-on-a-chip systems to minimize the amount of sample/solvents to few microliters only, substitution of harmful solvents with green alternatives, minimal waste generation or proper treatment of waste and biodegradable and biocompatible platforms for fabricating lab-on-a-chip devices have been discussed in details. Additionally, the challenges that may hinder their commercialization are also critically discussed.