Multistate proteinous biomemory device based on redox controllable hapten cross-linker

GÜZEL R., ERSÖZ A., DOLAK İ., Say R.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, cilt.79, ss.336-342, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 79
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.msec.2017.05.026
  • Dergi Adı: MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.336-342
  • Anahtar Kelimeler: Multistate biomemory device, Nanobiochip, Ruthenium based amino acid monomer hapten, Polymeric proteinous memory layer, Open-circuit potential amperometry, BIOELECTRONIC DEVICE, BIOSENSORS, BEHAVIOR, ASSAY
  • Anadolu Üniversitesi Adresli: Evet

Özet

A multistate biomemory device consisting of cytochrome c (Cyt-c) photosensitively cross-linked by MACysRu(bipyr)(2)-MACys hapten molecules, which have memory effect through a charge transfer mechanism, has been developed. In this study, it has suggested a highly resolute surface-confined switch composed a signal-enhanced electro-active protein (Cyt-c) co-polymerized on the gold substrates that can be controlled by redox property through Ruthenium based cysteine monomer hapten, MACys-Ru(bipyr)(2)-MACys as an ANADOLUCA photosensitive cross-linker. The photosensitive cross-linking of the Cyt-c protein on the gold surface topography has been determined by the scanning electron microscopy (SEM). Two state memory functions, writing and erasing of the developed biomemory device, have been investigated by the chronoamperometry (CA) and open-circuit potential amperometry (OCPA). The polymeric proteinous memory device, p(MACys-Ru(bipyr)(2)-MACys-coCyt-c) layer, on the gold electrode is stable and repeatable up to with 10(4) times continuous cycle. (C) 2017 Elsevier B.V. All rights reserved.