The Role of TRP and K+ Ion Channels in Analgesic Effect of NSAIDs
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.8, sa.4, ss.301-307, 2018 (ESCI, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 4
- Basım Tarihi: 2018
- Doi Numarası: 10.5152/clinexphealthsci.2018.832
- Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.301-307
- Anahtar Kelimeler: NSAIDs, TRP channel, potassium channels, analgesia, POTASSIUM CHANNELS, PAIN, DICLOFENAC, RETIGABINE, RECEPTOR, ACID, ANTINOCICEPTION
- Anadolu Üniversitesi Adresli: Evet
Özet
Objective: We aimed to clarify the possible contributions of TRP and voltage-dependent K+ channels to the analgesic effects of diclofenac, ketoprofen, etodolac, and dipyrone using the nonselective TRP channel blocker ruthenium red and the voltage-dependent K+ channel blocker (Kv7; KCNQ) XE 991, respectively.