The Role of TRP and K+ Ion Channels in Analgesic Effect of NSAIDs

ARSLAN R., BEKTAŞ TÜRKMEN N.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.8, sa.4, ss.301-307, 2018 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5152/clinexphealthsci.2018.832
  • Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.301-307
  • Anahtar Kelimeler: NSAIDs, TRP channel, potassium channels, analgesia, POTASSIUM CHANNELS, PAIN, DICLOFENAC, RETIGABINE, RECEPTOR, ACID, ANTINOCICEPTION
  • Anadolu Üniversitesi Adresli: Evet

Özet

Objective: We aimed to clarify the possible contributions of TRP and voltage-dependent K+ channels to the analgesic effects of diclofenac, ketoprofen, etodolac, and dipyrone using the nonselective TRP channel blocker ruthenium red and the voltage-dependent K+ channel blocker (Kv7; KCNQ) XE 991, respectively.