The Role of TRP and K+ Ion Channels in Analgesic Effect of NSAIDs

ARSLAN R., BEKTAŞ TÜRKMEN N.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.8, no.4, pp.301-307, 2018 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.5152/clinexphealthsci.2018.832
  • Journal Name: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.301-307
  • Keywords: NSAIDs, TRP channel, potassium channels, analgesia, POTASSIUM CHANNELS, PAIN, DICLOFENAC, RETIGABINE, RECEPTOR, ACID, ANTINOCICEPTION
  • Anadolu University Affiliated: Yes

Abstract

Objective: We aimed to clarify the possible contributions of TRP and voltage-dependent K+ channels to the analgesic effects of diclofenac, ketoprofen, etodolac, and dipyrone using the nonselective TRP channel blocker ruthenium red and the voltage-dependent K+ channel blocker (Kv7; KCNQ) XE 991, respectively.