Bitargeting and ambushing nanotheranostics

Say R., UZUN L., Yazar S., DENİZLİ A., HÜR D., Yilmaz F., ...More

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, vol.42, no.2, pp.138-145, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.3109/21691401.2013.794359
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.138-145
  • Keywords: bi-targeting, cytochrome P450, controlled cancer cell apoptosis, fluorescent nanoparticles, ifosfamide, nanotheranostics, quantum dots, IMPRINTED NANOSHELL, PRODRUG-ACTIVATION, P-450 REDUCTASE, GENE-THERAPY, CANCER, NANOPARTICLE, CYCLOPHOSPHAMIDE, DELIVERY, IDENTIFICATION, POTENTIATION
  • Anadolu University Affiliated: Yes


The main problem in cancer chemotherapy is the cytotoxic side effects of therapeutics on healthy tissues and cells. The targeted drug delivery and nanotechnology are intensively investigated area to find new ways to solve, at least to reduce, these problems. Hereby, we have reported a new method inspired from both conventional military strategies and biorecognition in the body. In this respect, we have produced two fluorescent nano-drug systems with bitargeting and biorecognition properties, recognizing cancer cells and each other. The multiplexed nanostructures were interacted with HL-60 cells to show their efficiency for bitargeting, ambushing, timed, and double-controlled cancer cell apoptosis.