Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an In Vitro Evaluation
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.14, no.2, pp.191-200, 2017 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 14 Issue: 2
- Publication Date: 2017
- Doi Number: 10.4274/tjps.69855
- Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.191-200
- Keywords: Dirithromycin, Kollidon (R) SR, polymeric nanoparticles, ocular drug delivery, SOLID LIPID NANOPARTICLES, KOLLIDON(R) SR, CYCLOSPORINE-A, DRUG-DELIVERY, PHARMACEUTICAL APPLICATIONS, CHITOSAN NANOPARTICLES, DISSOLUTION PROFILES, CONTROLLED-RELEASE, VIVO EVALUATION, STABILITY
- Open Archive Collection: AVESIS Open Access Collection
- Anadolu University Affiliated: Yes
Abstract
Objectives: Ocular drug delivery is a difficult challenge especially with topical intillation which results in rapid drainage and non-productive drug absorption. For the improvement of the pre-corneal retention time and enhancing the corneal permeability, colloidal drug delivery systems play an important role in enhancement of the ocular bioavailability. In this study, dirithromycin incorporated Kollidon (R) SR-based polymeric nanoparticles, an antibacterial agent, were formulated for the efficient treatment of severe ocular bacterial infections.