Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an In Vitro Evaluation

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BAŞARAN E.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.14, no.2, pp.191-200, 2017 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.4274/tjps.69855
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.191-200
  • Keywords: Dirithromycin, Kollidon (R) SR, polymeric nanoparticles, ocular drug delivery, SOLID LIPID NANOPARTICLES, KOLLIDON(R) SR, CYCLOSPORINE-A, DRUG-DELIVERY, PHARMACEUTICAL APPLICATIONS, CHITOSAN NANOPARTICLES, DISSOLUTION PROFILES, CONTROLLED-RELEASE, VIVO EVALUATION, STABILITY
  • Anadolu University Affiliated: Yes

Abstract

Objectives: Ocular drug delivery is a difficult challenge especially with topical intillation which results in rapid drainage and non-productive drug absorption. For the improvement of the pre-corneal retention time and enhancing the corneal permeability, colloidal drug delivery systems play an important role in enhancement of the ocular bioavailability. In this study, dirithromycin incorporated Kollidon (R) SR-based polymeric nanoparticles, an antibacterial agent, were formulated for the efficient treatment of severe ocular bacterial infections.