Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an In Vitro Evaluation

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BAŞARAN E.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.14, sa.2, ss.191-200, 2017 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjps.69855
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.191-200
  • Anahtar Kelimeler: Dirithromycin, Kollidon (R) SR, polymeric nanoparticles, ocular drug delivery, SOLID LIPID NANOPARTICLES, KOLLIDON(R) SR, CYCLOSPORINE-A, DRUG-DELIVERY, PHARMACEUTICAL APPLICATIONS, CHITOSAN NANOPARTICLES, DISSOLUTION PROFILES, CONTROLLED-RELEASE, VIVO EVALUATION, STABILITY
  • Anadolu Üniversitesi Adresli: Evet

Özet

Objectives: Ocular drug delivery is a difficult challenge especially with topical intillation which results in rapid drainage and non-productive drug absorption. For the improvement of the pre-corneal retention time and enhancing the corneal permeability, colloidal drug delivery systems play an important role in enhancement of the ocular bioavailability. In this study, dirithromycin incorporated Kollidon (R) SR-based polymeric nanoparticles, an antibacterial agent, were formulated for the efficient treatment of severe ocular bacterial infections.