TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.14, no.2, pp.191-200, 2017 (ESCI)
Article / Article
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
Dirithromycin, Kollidon (R) SR, polymeric nanoparticles, ocular drug delivery, SOLID LIPID NANOPARTICLES, KOLLIDON(R) SR, CYCLOSPORINE-A, DRUG-DELIVERY, PHARMACEUTICAL APPLICATIONS, CHITOSAN NANOPARTICLES, DISSOLUTION PROFILES, CONTROLLED-RELEASE, VIVO EVALUATION, STABILITY
Anadolu University Affiliated:
Objectives: Ocular drug delivery is a difficult challenge especially with topical intillation which results in rapid drainage and non-productive drug absorption. For the improvement of the pre-corneal retention time and enhancing the corneal permeability, colloidal drug delivery systems play an important role in enhancement of the ocular bioavailability. In this study, dirithromycin incorporated Kollidon (R) SR-based polymeric nanoparticles, an antibacterial agent, were formulated for the efficient treatment of severe ocular bacterial infections.