Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an In Vitro Evaluation
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.14, sa.2, ss.191-200, 2017 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 2
- Basım Tarihi: 2017
- Doi Numarası: 10.4274/tjps.69855
- Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.191-200
- Anahtar Kelimeler: Dirithromycin, Kollidon (R) SR, polymeric nanoparticles, ocular drug delivery, SOLID LIPID NANOPARTICLES, KOLLIDON(R) SR, CYCLOSPORINE-A, DRUG-DELIVERY, PHARMACEUTICAL APPLICATIONS, CHITOSAN NANOPARTICLES, DISSOLUTION PROFILES, CONTROLLED-RELEASE, VIVO EVALUATION, STABILITY
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Anadolu Üniversitesi Adresli: Evet
Özet
Objectives: Ocular drug delivery is a difficult challenge especially with topical intillation which results in rapid drainage and non-productive drug absorption. For the improvement of the pre-corneal retention time and enhancing the corneal permeability, colloidal drug delivery systems play an important role in enhancement of the ocular bioavailability. In this study, dirithromycin incorporated Kollidon (R) SR-based polymeric nanoparticles, an antibacterial agent, were formulated for the efficient treatment of severe ocular bacterial infections.