Synthesis of New Thiazolyl-pyrazoline Derivatives and Evaluation of Their Antimicrobial, Cytotoxic and Genotoxic Effects

SEVER B., ALTINTOP M. D., Gencer H., KAPKAÇ H. A., ATLI EKLİOĞLU Ö., BAYSAL M., ...More

LETTERS IN DRUG DESIGN & DISCOVERY, vol.15, no.7, pp.744-756, 2018 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 15 Issue: 7
  • Publication Date: 2018
  • Doi Number: 10.2174/1570180814666170925152902
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.744-756
  • Keywords: Pyrazoline, thiazole, antimicrobial activity, cytotoxicity, genotoxicity, anticancer, THIOSEMICARBAZONE DERIVATIVES, BIOLOGICAL EVALUATION, ANTIFUNGAL ACTIVITY, POTENT ANTIFUNGAL, CANDIDA-ALBICANS, DRUG DISCOVERY, CANCER, RESISTANCE, INHIBITORS, MECHANISMS
  • Anadolu University Affiliated: Yes

Abstract

Background: Pyrazolines have played a pivotal role in antimicrobial and anticancer drug discovery. Moreover, thiazoles have attracted a great deal of interest due to their crucial roles in the lead identification and optimization.