Synthesis of New Thiazolyl-pyrazoline Derivatives and Evaluation of Their Antimicrobial, Cytotoxic and Genotoxic Effects

SEVER, BELGİN; ALTINTOP, MEHLİKA; Gencer, HÜLYA; KAPKAÇ, HANDAN; ATLI EKLİOĞLU, ÖZLEM; BAYSAL, MERVE; ÖZDEMİR, AHMET

doi:10.2174/1570180814666170925152902

Synthesis of New Thiazolyl-pyrazoline Derivatives and Evaluation of Their Antimicrobial, Cytotoxic and Genotoxic Effects

SEVER B., ALTINTOP M. D., Gencer H., KAPKAÇ H. A., ATLI EKLİOĞLU Ö., BAYSAL M., ...Daha Fazla

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.15, sa.7, ss.744-756, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 15 Sayı: 7
Basım Tarihi: 2018
Doi Numarası: 10.2174/1570180814666170925152902
Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.744-756
Anahtar Kelimeler: Pyrazoline, thiazole, antimicrobial activity, cytotoxicity, genotoxicity, anticancer, THIOSEMICARBAZONE DERIVATIVES, BIOLOGICAL EVALUATION, ANTIFUNGAL ACTIVITY, POTENT ANTIFUNGAL, CANDIDA-ALBICANS, DRUG DISCOVERY, CANCER, RESISTANCE, INHIBITORS, MECHANISMS
Anadolu Üniversitesi Adresli: Evet

Özet

Background: Pyrazolines have played a pivotal role in antimicrobial and anticancer drug discovery. Moreover, thiazoles have attracted a great deal of interest due to their crucial roles in the lead identification and optimization.