BETA-ADRENERGIC RESPONSIVENESS OF THE GASTROINTESTINAL-TRACT IN DIABETIC RATS
PHARMACOLOGY & TOXICOLOGY, cilt.71, sa.4, ss.250-253, 1992 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 71 Sayı: 4
- Basım Tarihi: 1992
- Doi Numarası: 10.1111/j.1600-0773.1992.tb00978.x
- Dergi Adı: PHARMACOLOGY & TOXICOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.250-253
- Anadolu Üniversitesi Adresli: Evet
Özet
Recently, decreased gastrointestinal beta-adrenergic responses in experimental diabetes have been demonstrated. Gastrointestinal responses to beta-adrenoceptor agonists are impaired in both insulin-dependent and non-insulin-dependent diabetic rat. Insulin treatment improves the impaired gastrointestinal beta-adrenergic responsiveness of diabetic rats. The improvement seen with insulin treatment on beta-adrenergic responsiveness is closely related to protein biosynthesis. The decreased beta-adrenergic responses in diabetic rat gastrointestinal tract seem to result from a decrease in the number of beta-adrenoceptors. It is most likely that the decreased gastrointestinal beta-adrenergic responsiveness is related to an impairment in the turnover of beta-adrenoceptors as a consequence of diabetes and that insulin has a beneficial effect on the impaired receptor turnover.