CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF KITAIBELIA BALANSAE BOISS
FARMACIA, vol.67, no.6, pp.1054-1059, 2019 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 67 Issue: 6
- Publication Date: 2019
- Doi Number: 10.31925/farmacia.2019.6.17
- Journal Name: FARMACIA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1054-1059
- Keywords: Kitaibelia balansae, Malvaceae, HPLC/MS/MS, anti-inflammatory, DAD-ESI-MSN, PHENOLIC-COMPOUNDS, IN-VITRO, ANTIOXIDANT, FRUITS, QUANTIFICATION, IDENTIFICATION, FLAVONOIDS, EXTRACT, RUTIN
- Open Archive Collection: AVESIS Open Access Collection
- Anadolu University Affiliated: Yes
Abstract
Aerial part extracts of Kitaibelia balansae Boiss. were examined for their phenolic contents, as well as anti-inflammatory activities. The chemical compositions of the extracts were analysed by spectrophotometric and chromatographic (HPLC/ MS/MS and HPLC-PDA) approaches. To measure anti-inflammatory activity, the effects of the extracts on nitric oxide (NO) and Tumour Necrosis Factor-alpha (TNF-alpha) levels were measured in lipopolysaccharide (LPS) treated murine macrophage cell line (RAW 264.7). The ethyl acetate fraction was found to be abundant in phenolic compounds (259.78 +/- 15.07 mg(GAE)/gextract). Rutin was identified as the major compound in all the extracts. The ethyl acetate fraction potentially inhibited NO and TNF-alpha production (37.26 mu M and 1781.524 pg/mL, respectively, 6 h) in LPS induced cells.