Spectroscopic Determination and Evaluation of Acidity Constants for Some Drug Precursor 2-Amino-4-(3-or 4-substituted phenyl) Thiazole Derivatives

Ogretir, Cemil; DEMİRAYAK, ŞEREF; DURAN, MURAT

doi:10.1021/je9005739

Spectroscopic Determination and Evaluation of Acidity Constants for Some Drug Precursor 2-Amino-4-(3-or 4-substituted phenyl) Thiazole Derivatives

Ogretir C., DEMİRAYAK Ş., DURAN M.

JOURNAL OF CHEMICAL AND ENGINEERING DATA, vol.55, no.3, pp.1137-1142, 2010 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 55 Issue: 3
Publication Date: 2010
Doi Number: 10.1021/je9005739
Journal Name: JOURNAL OF CHEMICAL AND ENGINEERING DATA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1137-1142
Anadolu University Affiliated: No

Abstract

Acid dissociation constants, K-a, of eight drug precursor 2-amino-4-(3- or 4-substituted phenyl) thiazole derivatives were determined using a UV-vis spectroscopic technique. The obtained K-a values were evaluated by Structure elucidation and a protonation mechanism. The obtained tautomerization equilibrium constants, K-T, indicated the predominance of amino forms for all studied compounds.