Rutin enhances the analgesic efficacy of low-dose pregabalin without sedative side effects in a rat model of chronic constriction injury
Journal of Pharmacy and Pharmacology, cilt.78, sa.5, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78 Sayı: 5
- Basım Tarihi: 2026
- Doi Numarası: 10.1093/jpp/rgag054
- Dergi Adı: Journal of Pharmacy and Pharmacology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE
- Anahtar Kelimeler: chronic constriction injury, combination therapy, neuropathic pain, pregabalin, rutin
- Anadolu Üniversitesi Adresli: Evet
Özet
Objectives: The aim of this study was to evaluate the antiallodynic and antihyperalgesic effects of rutin alone and in combination with pregabalin in a chronic constriction injury-induced neuropathic pain model. Methods: The potential antiallodynic and antihyperalgesic effects of combining rutin at doses of 25, 50, and 100 mg/kg with 3 mg/kg of pregabalin were evaluated in a rat neuropathic pain model induced by chronic constriction injury. Assessments were conducted over a 180-minute period using an electronic von Frey device and the plantar test. Spontaneous locomotor activity was evaluated using a Plexiglas activity cage. Key findings: All combination groups exhibited statistically significant antiallodynic and antihyperalgesic effects at specific time intervals compared to the groups where rutin or 3 mg/kg pregabalin were administered alone. Furthermore, the efficacy of the combinations was found to be comparable to that of the group treated with 30 mg/kg pregabalin. The 25 mg/kg rutin combination was most effective and independent of locomotor activity. Conclusions: Given rutin’s low side-effect profile and the dose-dependent risks of pregabalin, their combination at low-dose pregabalin may represent a safe and effective alternative for neuropathic pain treatment.