Synthesis of some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives and their antimicrobial activity and toxicity

Turan-Zitouni G., Demirayak E., ÖZDEMİR A., KAPLANCIKLI Z. A., Yildiz M.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.39, sa.3, ss.267-272, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.ejmech.2003.11.001
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.267-272
  • Anahtar Kelimeler: thiazole, benzothiazole, benzimidazole, benzoxazole, antimicrobial activity, WATER MARINE SPONGES, BENZIMIDAZOLE DERIVATIVES, MICROBIOLOGICAL ACTIVITY, FAMILY PACHASTRELLIDAE, REVERSE-TRANSCRIPTASE, BENZOXAZOLES, ALKALOIDS, OXAZOLO(4,5-B)PYRIDINES, ZIDOVUDINE, L-697,661
  • Anadolu Üniversitesi Adresli: Evet

Özet

Some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives (III) were synthesized by reacting 4-methyl-2-(chloroacetylamino)thiazole derivatives (I) with benzazol-2-thiole (II) in acetone in the presence of K2CO3. The chemical structures of the compounds were elucidated by H-1 NMR and FAB(+)-MS spectral data. The prepared compounds were tested for antimicrobial activity and toxicity. (C) 2003 Elsevier SAS. All rights reserved.