Synthesis of some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives and their antimicrobial activity and toxicity

Turan-Zitouni G., Demirayak E., ÖZDEMİR A., KAPLANCIKLI Z. A., Yildiz M.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.39, no.3, pp.267-272, 2004 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 39 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1016/j.ejmech.2003.11.001
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.267-272
  • Keywords: thiazole, benzothiazole, benzimidazole, benzoxazole, antimicrobial activity, WATER MARINE SPONGES, BENZIMIDAZOLE DERIVATIVES, MICROBIOLOGICAL ACTIVITY, FAMILY PACHASTRELLIDAE, REVERSE-TRANSCRIPTASE, BENZOXAZOLES, ALKALOIDS, OXAZOLO(4,5-B)PYRIDINES, ZIDOVUDINE, L-697,661
  • Anadolu University Affiliated: Yes

Abstract

Some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives (III) were synthesized by reacting 4-methyl-2-(chloroacetylamino)thiazole derivatives (I) with benzazol-2-thiole (II) in acetone in the presence of K2CO3. The chemical structures of the compounds were elucidated by H-1 NMR and FAB(+)-MS spectral data. The prepared compounds were tested for antimicrobial activity and toxicity. (C) 2003 Elsevier SAS. All rights reserved.