APOPTOTIC EFFECTS OF PUNICALAGIN ON PARTIALLY HEPATECTOMIZED RAT LIVER

ARTAGAN Ö., ALANYALI F., CANBEK M.

COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES, vol.73, no.8, pp.1160-1168, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 8
  • Publication Date: 2020
  • Doi Number: 10.7546/crabs.2020.08.16
  • Journal Name: COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, zbMATH
  • Page Numbers: pp.1160-1168
  • Keywords: NF kappa B, caspase-3, RT-PCR, TUNEL method, Taq-Man protein assay, punicalagin, POMEGRANATE JUICE, ANTIOXIDANT, ACID
  • Anadolu University Affiliated: Yes

Abstract

The antioxidant potential of pomegranate is attributed to its polyphenols, including punicalagin. In this study, we searched the effects of punicalagin on 70% partially hepatectomized rats. Animals were subjected to partial hepatectomy (PH), immediately after receiving 15 mg/kg punicalagin. They were dissected at different time points (3 h, 6 h) following surgery. NF-kappaB (NF kappa B), caspase-3 gene expression results were evaluated by RT-PCR and protein expression fold changes were evaluated according to the qPCR method. Apoptotic index results were compared between groups.