Synthesis, Antituberculotic, and Cytotoxic Properties of New Hydrazone Derivatives Bearing Pyrimidine-Alkylsulfanyl Moiety

YURTTAŞ L., KAPLANCIKLI Z. A., CANTÜRK Z., Gencer H. K.

Phosphorus, Sulfur and Silicon and the Related Elements, cilt.190, sa.7, ss.1183-1191, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 190 Sayı: 7
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1080/10426507.2014.979984
  • Dergi Adı: Phosphorus, Sulfur and Silicon and the Related Elements
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.1183-1191
  • Anahtar Kelimeler: Pyrimidine, hydrazone, alkylsulfanyl, antituberculotic, cytotoxic, MYCOBACTERIUM-TUBERCULOSIS, ANTIMYCOBACTERIAL ACTIVITY, BENZIMIDAZOLE DERIVATIVES, IN-VITRO, ACID, SERIES
  • Anadolu Üniversitesi Adresli: Evet

Özet

© 2015 Copyright Taylor & Francis Group, LLC.A series of N'-(arylidene)-4-[(pyrimidine-2-yl)thio]butanohydrazide derivatives (3a-3m) has been synthesized and investigated for their antituberculotic and cytotoxic activity. The antitubercular activities of the newly synthesized compounds were tested against Mycobacterium tuberculosis H37Rv strain by MABA (Microplate Alamar Blue Assay) method and cytotoxic properties were tested against NIH/3T3 and A549 cell lines by MTT method. The title compounds have been exhibited moderate antitubercular activity. Compound 3m, titled N'-(4-nitrobenzylidene)-4-[(pyrimidine-2-yl)thio]butanohydrazide showed promising cytotoxic activity when compared with the standard drug.