Synthesis and anticancer activity of some bisquinoxaline derivatives Bazi biskinoksalin türevlerinin sentezleri ve antikanser aktiviteleri

IŞIKDAĞ İ., ÖZKAY Y., Incesu Z.

Turkish Journal of Pharmaceutical Sciences, cilt.8, sa.2, ss.179-188, 2011 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 2
  • Basım Tarihi: 2011
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.179-188
  • Anahtar Kelimeler: Anticancer, Bisquinoxaline derivatives, Cytotoxicity, DNA synthesis inhibition
  • Anadolu Üniversitesi Adresli: Evet

Özet

Resistance improvement against the existing anticancer agents creates a research area for new anticancer agents. Nevertheless, it is rather difficult to develop a new agent which can selectively inhibit the proliferation of abnormal cells with least or no affect on normal cells. Therefore, cancer chemotherapy is very important for medicinal chemists and the studies are still being carried on to develop new chemotherapeutic agents that are probable to indicate activity on various cancer types. Depending on this point, in this study some bisquinoxaline derivatives were synthesized and screened for their anticancer activity on HT-29 (colon carcinoma) and MCF-7(breast carcinoma) cell lines. Some of the synthesized compounds (3e and 3l) showed significant cytotoxicity and DNA synthesis inhibition on MCF-7 cell line.