Synthesis of Some Imidazo[1,2-a]pyrazine Derivatives and Evaluation of Their Antinociceptive Activity

Turan-Zitouni G., YURTTAŞ L., ÖZDEMİR A., KAPLANCIKLI Z. A., Masquefa C.

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.6, sa.1, ss.9-13, 2016 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/clinexphealthsci.2016.024
  • Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.9-13
  • Anahtar Kelimeler: Antinociceptive, hydrazone, imidazopyrazine, hot plate, writhing test
  • Anadolu Üniversitesi Adresli: Evet

Özet

Objective: The imidazopyrazine ring is a biologically active heterocyclic ring. Many hydrazide-hydrazone-possessing compounds have been reported to have interesting bioactivity, such as antibacterial, antifungal, anticonvulsant, anti-inflammatory, antituberculosis, and analgesic activities. In particular, aroyl hydrazides/hydrazone-containing hetero-rings, such as indole, pyridine, and imidazo[2,1-b]pyridine, and imidazo[1,2-a]pyrazine, have attracted special attention. We designed and synthesized N-(4-substitutedbenzylidene) imidazo[1,2-a]pyrazine-2-carbohydrazide (2a-j) derivatives using the two aforementioned pharmacophoric units based on the synthetic procedure indicated in our previous study.