Synthesis of Some Imidazo[1,2-a]pyrazine Derivatives and Evaluation of Their Antinociceptive Activity
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, vol.6, no.1, pp.9-13, 2016 (ESCI, TRDizin)
- Publication Type: Article / Article
- Volume: 6 Issue: 1
- Publication Date: 2016
- Doi Number: 10.5152/clinexphealthsci.2016.024
- Journal Name: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
- Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Page Numbers: pp.9-13
- Keywords: Antinociceptive, hydrazone, imidazopyrazine, hot plate, writhing test
- Anadolu University Affiliated: Yes
Abstract
Objective: The imidazopyrazine ring is a biologically active heterocyclic ring. Many hydrazide-hydrazone-possessing compounds have been reported to have interesting bioactivity, such as antibacterial, antifungal, anticonvulsant, anti-inflammatory, antituberculosis, and analgesic activities. In particular, aroyl hydrazides/hydrazone-containing hetero-rings, such as indole, pyridine, and imidazo[2,1-b]pyridine, and imidazo[1,2-a]pyrazine, have attracted special attention. We designed and synthesized N-(4-substitutedbenzylidene) imidazo[1,2-a]pyrazine-2-carbohydrazide (2a-j) derivatives using the two aforementioned pharmacophoric units based on the synthetic procedure indicated in our previous study.