Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms

Creative Commons License

ALYU ALTINOK F., DİKMEN M.

ACTA NEUROPSYCHIATRICA, vol.29, no.1, pp.1-16, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 29 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.1017/neu.2016.47
  • Journal Name: ACTA NEUROPSYCHIATRICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1-16
  • Keywords: epilepsy, epileptogenesis, inflammation, BLOOD-BRAIN-BARRIER, TEMPORAL-LOBE EPILEPSY, TUBEROUS SCLEROSIS COMPLEX, CENTRAL-NERVOUS-SYSTEM, SPONTANEOUS RECURRENT SEIZURES, INDUCED STATUS EPILEPTICUS, NECROSIS-FACTOR-ALPHA, STIFF-PERSON SYNDROME, MAMMALIAN TARGET, MTOR INHIBITORS
  • Anadolu University Affiliated: Yes

Abstract

Objective Epilepsy is a chronic neurological disease characterised with seizures. The aetiology of the most generalised epilepsies cannot be explicitly determined and the seizures are pronounced to be genetically determined by disturbances of receptors in central nervous system. Besides, neurotransmitter distributions or other metabolic problems are supposed to involve in epileptogenesis. Lack of adequate data about pharmacological agents that have antiepileptogenic effects point to need of research on this field. Thus, in this review, inflammatory aspects of epileptogenesis has been focussed via considering several concepts like role of immune system, blood-brain barrier and antibody involvement in epileptogenesis.