INCREASED ALPHA(1)-ADRENERGIC RESPONSIVENESS OF ALLOXAN-DIABETIC RAT ATRIA - EFFECTS OF INSULIN THERAPY AND THYROIDECTOMY

LAFCIEROL D., ALTAN V., ÖZTÜRK Y.

GENERAL PHARMACOLOGY, vol.25, no.3, pp.559-564, 1994 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 3
  • Publication Date: 1994
  • Doi Number: 10.1016/0306-3623(94)90214-3
  • Journal Name: GENERAL PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.559-564
  • Keywords: INSULIN, THYROIDECTOMY, CARDIOVASCULAR COMPLICATIONS, SPONTANEOUSLY BEATING ATRIA, ALPHA-ADRENOCEPTORS, ALLOXAN-DIABETES, PHENYLEPHRINE, LEFT-VENTRICULAR FUNCTION, ALPHA-ADRENOCEPTOR STIMULATION, CARDIAC-PERFORMANCE, VASA DEFERENTIA, MELLITUS, CARDIOMYOPATHY, HEARTS, NOREPINEPHRINE, RECEPTORS, RESPONSES
  • Anadolu University Affiliated: Yes

Abstract

1. Experimental models of diabetes are increasingly used for the investigation of cardiovascular complications as well as other complications due to diabetes mellitus. However, animal models have been used in relatively few studies on the myocardial alpha(1)-adrenergic responses. Hence, this report describes the effect of alloxan-induced diabetes and insulin-treatment on the alpha(1)-adrenergic responses of this isolated rat atria.