Synthesis, In vitro and In silico Evaluation of a Series of Pyrazolines as New Anticholinesterase Agents

ALTINTOP M. D.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.17, sa.5, ss.574-584, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1570180816666190618111023
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE
  • Sayfa Sayıları: ss.574-584
  • Anahtar Kelimeler: Acetylcholinesterase, molecular docking, piperidine, pyrazoline, anticholinesterase agents, ADME, ALZHEIMERS-DISEASE, CHOLINESTERASE, DERIVATIVES, INHIBITORS, ACETYLCHOLINESTERASE, DONEPEZIL
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: Pyrazolines, electron-rich nitrogen carriers, are of great importance due to their potential applications for the treatment of many diseases including inflammation, infectious diseases and neurodegenerative disorders.