Synthesis, In vitro and In silico Evaluation of a Series of Pyrazolines as New Anticholinesterase Agents

ALTINTOP M. D.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.17, no.5, pp.574-584, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.2174/1570180816666190618111023
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE
  • Page Numbers: pp.574-584
  • Keywords: Acetylcholinesterase, molecular docking, piperidine, pyrazoline, anticholinesterase agents, ADME, ALZHEIMERS-DISEASE, CHOLINESTERASE, DERIVATIVES, INHIBITORS, ACETYLCHOLINESTERASE, DONEPEZIL
  • Anadolu University Affiliated: Yes

Abstract

Background: Pyrazolines, electron-rich nitrogen carriers, are of great importance due to their potential applications for the treatment of many diseases including inflammation, infectious diseases and neurodegenerative disorders.