Synthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.31, no.5, pp.714-720, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 31 Issue: 5
- Publication Date: 2016
- Doi Number: 10.3109/14756366.2015.1060481
- Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
- Page Numbers: pp.714-720
- Keywords: 2-Mercaptobenzothiazole, anticandidal, antifungal, hydrazone, ANTIMICROBIAL ACTIVITY, THIAZOLE DERIVATIVES, ANTIFUNGAL ACTIVITY, CYTOTOXICITY, INFECTIONS
- Open Archive Collection: AVESIS Open Access Collection
- Anadolu University Affiliated: Yes
Abstract
In this study, we have performed the synthesis of new N-(arylidene)-4-[(benzothiazol-2-yl)thio]butanoylhydrazide derivatives (3a-s) bearing azole moiety and hydrazone group in a lipophilic structural framework. The target compounds were prepared by a three step synthetic procedure starting from 2-mercaptobenzothiazole. The structures of the target compounds were elucidated by IR, H-1 NMR, C-13 NMR spectra and elemental analysis. The antifungal activity of the obtained compounds has been determined against a number of clinic and fluconazole-resistant Candida strains by using microdilution method. Compounds (3a-3s) exhibited anticandidal activity in different ratios varying between the range of MIC: 50 and 200 mu g/mL.