Synthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety

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YURTTAŞ L., KAPLANCIKLI Z. A., Goger G., DEMİRCİ F.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.31, sa.5, ss.714-720, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/14756366.2015.1060481
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.714-720
  • Anahtar Kelimeler: 2-Mercaptobenzothiazole, anticandidal, antifungal, hydrazone, ANTIMICROBIAL ACTIVITY, THIAZOLE DERIVATIVES, ANTIFUNGAL ACTIVITY, CYTOTOXICITY, INFECTIONS
  • Anadolu Üniversitesi Adresli: Evet

Özet

In this study, we have performed the synthesis of new N-(arylidene)-4-[(benzothiazol-2-yl)thio]butanoylhydrazide derivatives (3a-s) bearing azole moiety and hydrazone group in a lipophilic structural framework. The target compounds were prepared by a three step synthetic procedure starting from 2-mercaptobenzothiazole. The structures of the target compounds were elucidated by IR, H-1 NMR, C-13 NMR spectra and elemental analysis. The antifungal activity of the obtained compounds has been determined against a number of clinic and fluconazole-resistant Candida strains by using microdilution method. Compounds (3a-3s) exhibited anticandidal activity in different ratios varying between the range of MIC: 50 and 200 mu g/mL.